Manuscript Types

Research Articles

Manuscript on original studies should be submitted as Research Articles. The sections should be prepared as follows:

•     Introduction: The introduction should clearly show the objective of the study, provide a brief summary of previous relevant studies, and demonstrate the new advances in the current investigation.

•     Materials and Methods: This section should briefly give clear and solid information to allow duplication by an independent observer.

•     Results: The results should be a concise and logical account of the new information discovered, with the least personal judgment.

•     Discussion: The discussion should incorporate the significance of the new information and relevance of the novel findings in light of existing knowledge. Limitations should also be stated.

•     Conclusions: The conclusions should be drawn clearly and concisely (less than five sentences).

More information is available in the Research Article sample.

Review Articles

Review articles aim to provide accessible, authoritative overviews of a field or topic. Potential authors should keep in mind that they are expected to have expertise in the reviewed field. The sections should be arranged as follows:

•     Review articles have a flexible format with no restricted length.

•     If appropriate, the method of reference collection should be described.

•     The use of headings, subheadings, and paragraph titles is recommended to improve clarity.

•     Conclusions: The conclusions should be drawn clearly and concisely (less than five sentences).

More information is available in the Review Article sample.

Case Reports

A case report is a detailed report of the symptoms, signs, diagnosis, treatment, follow-up and outcomes of a certain disease.

The article should include to the following four parts: introduction, case report or clinical series, discussion, conclusions.

More information is available in the Case Report sample.

For articles published in Science Immunity & Inflammation Reviews, please see the following content for your reference:

Review

A review article offers a systematic synthesis and in-depth analysis of existing research within a specific academic field. Its primary objective is to comprehensively map the evolution of the topic,  assess the current development state, and identify emerging trends. Authors are expected to conduct extensive literature searches and integrate a broad range of sources, engaging in multidimensional evaluations ofthe subject.

Such  manuscripts  should  objectively  present  key  arguments,  methodologies,  and conclusions from previous studies, and also provide a critical appraisal, articulating existing limitations to guide future investigations.

As for the length of the content, the main body is recommended to range between 10,000 and 20,000 words. Each submission should include a minimum of 10 figures or tables to aid in data visualization. There is no fixed limit on the number of references. Authors are encouraged to collaborate with colleagues both within and outside their home institutions, and international academic partnerships are particularly welcomed. Please note: For unsolicited review submissions (i.e., not directly commissioned or invited by the editorial team), authors are required to submit a presubmission inquiry to confirm alignment between the proposed topic and the journal’s scope.

Presubmission inquiries should be sent to: SIIR@zentimecorp.com.

Mini Review

A mini-review shares the same fundamental nature as a traditional review article but is more concise in scope and format. It focuses on a specific subfield or emerging research hotspot, aiming to present the latest developments and key advances on a targeted topic in a streamlined and efficient manner. Mini-reviews can help readers quickly grasp the forefront of academic research.

Compared to full-length reviews, mini-reviews cover a narrower range of literature and place greater emphasis on precision, synthesis, and clarity. They should distill essential content to ensure effective communication.

These  manuscripts   should  center  on  cutting-edge  topics,   selectively  incorporate references, and integrate the authors’ perspectives or hypotheses appropriately. The main text is recommended to range between 5,000 and 8,000 words, accompanied by at least four figures or tables. There is no fixed limit on the number of references. Authors  are  encouraged  to  collaborate  with  internal  and  external  experts,  and international co-authorship is highly welcomed.

Please note: For unsolicited mini-review submissions (i.e., not directly commissioned or invited by the editorial office), authors are required to submit a presubmission inquiry to confirm the alignment between the proposed topic and the journal’s scope. Presubmission inquiries should be sent to: SIIR@zentimecorp.com.

Perspectives

Perspective articles focus on the authors’ original insights, critical reflections, and forward-looking views on specific academic issues or research areas. Unlike traditional reviews that primarily summarize existing findings, perspective articles emphasize the authors’ expertise and experience to propose innovative ideas on future directions, potential breakthroughs, and emerging trends in the field.

Content  may  include  forward-thinking  analyses,  bold  academic  hypotheses,  and interdisciplinary  explorations,  with  the  goal  of  stimulating  scholarly  debate  and advancing disciplinary development.

Each perspective article should have no more than five authors and must include an abstract. The main text should not exceed 1,500 words, with a maximum of one figure or table and no more than 30 references.

Commentary

Commentary articles are concise academic pieces intended to provide a platform for authors to share their perspectives and insights on review articles previously published in this journal. These articles focus on high-impact or widely discussed topics within the field and aim to offer professional commentary, critique, or interpretation from a specialized viewpoint. The purpose is to promote academic dialogue by offering diverse perspectives and fostering deeper engagement with the subject matter.

Authors are expected to maintain objectivity and fairness, ensuring that their arguments are focused, critical, and constructive.

Commentaries are primarily invited by the editorial team, but unsolicited submissions are also welcome within one month of the online publication of the  corresponding review article.

Each commentary should be authored by no more than two individuals, with a main text length of 500–1,000 words (excluding the abstract). Submissions may include up to one figure or table (optional) and no more than 20 references. The editorial team will determine, on a case-by-case basis, whether peer review is required.

Letter

Letters are brief scholarly communications designed for the rapid dissemination of emerging academic developments. They typically provide concise commentary on cutting-edge topics or newly arising research questions within a specific field. Letters should emphasize both timeliness and originality, delivering focused discussions of key findings or contentious issues in a succinct format.

Each Letter should be authored by no more than three individuals, with the main text limited to 1,500 words. A maximum of two figures or tables may be included, and the number of references should not exceed 30.

Letters are generally processed through an accelerated peer-review system. Before submission, authors must ensure that the content has not been published or submitted to any other journal. All submissions must comply with standard academic ethics and meet the journal’s editorial and indexing requirements.

Expert Consensus

Expert consensus articles are collaboratively developed by a panel of authoritative experts    from    multiple     disciplines.    They     provide    unified,    evidence-based recommendations on practices, industry standards, or proposed solutions in response to specific questions or challenges within a given field. These documents represent a professional opinion formed through systematic evaluation of current research evidence, synthesis of clinical or practical experience, and analysis of real-world needs.

The primary aim of an expert consensus is to offer authoritative guidance for academic research, clinical practice, and policy-making.  Such  articles play  a pivotal role in advancing the structured development of the field and aligning research methodologies. Each expert consensus article must be co-authored by a team of at least 20 experts in the relevant domain.

Manuscript Format

Please note that articles must contain the following components:

Title Page

Ethics and Consent

Clinical Trials Registration

Highlights

Abstract & Keywords

Main Text

Acknowledgements

References

Figure legends

Units and Abbreviations

Please see below for further details

Title Page: The title page should include a manuscript title, authors’ name, affiliations, corresponding author’s contact information (full postal address, telephone and fax numbers and e-mail address) and conflicts of Interest (existed and potential conflicts of interest that authors may have).

Ethics and consent: Research involving human participants, human samples (tissue, blood, body fluid etc.), or human data, must have been conducted in accordance with the Declaration of Helsinki and must have been approved by an appropriate ethics committee. Research involving experiments on animals must demonstrate whether an institution's guide, a national research council's guide, or any national law on the care and use of laboratory animals was followed. A statement including the name of the ethics committee and the reference number, and Institutional Review Board (IRB) Approval Report or Ethics Committee Report must be provided if applicable. If a study has been granted an exemption from requiring ethics approval, this should also be stated in the manuscript. The Ethics and Consent should be disclosed both in the end of Title Page and in the Method part.

Patient consent: Research involving experiments with human subjects or tissues must include a statement declaring that informed consent was obtained from the subjects or guardians for participation in the study. Additionally, please anonymize the patient’s details as much as possible, which is a legal requirement. For studies with no personal information and very limited clinical data, or studies with a retrospective design, consent may be waived based on the opinions of the IRB. However, for case reports involving living patients, consent cannot be waived.

Clinical Trial Registration: Clinical trials refer to "any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate their effects on health outcomes". Purely observational studies do not require registration. Please provide the name of the registry of clinical trial, the trial number, and the trial URL when appropriate. The information of Clinical Trial Registration should be disclosed both in the Abstract and Method parts. Authors are strongly encouraged to pre-register clinical trials in suitable databases including clinicaltrials.gov, the EU Clinical Trials Register and those listed by the International Clinical Trials Registry Platform of World Health Organization.

Highlights: Highlights are bullet points that convey the core findings of your study. Highlights are mandatory for this journal. The manuscript may include up to three to five bullet points.

Abstract & Keywords: The abstract should briefly show the aim of the research, the results obtained and the major conclusions. The authors must include 3 to 5 key words or phrases at the end of the abstract.

Main Text: The manuscript body of RESEARCH ARTICLES should be organized in a standard form with the following separate sections: Introduction, Materials and Methods, Results, Discussion and Conclusion. REVIEW ARTICLES should be divided into sections and subsections as appropriate without numbering. Case reports should be organized in Introduction, Case Presentation, Results, and Conclusion.

Acknowledgements: The acknowledgments should clearly describe aids including financial supports (grant source and number should be specified), intellectual assistance, image credits etc.

References: The journal references should be formatted according to the EndNote X Style for Zentime ZENTIME PUBLISHING CORPORATION.zip.

Endnote Style：Journal Article

Author. Title. Journal Year;Volume(Issue):Pages.

e.g., Fan ZZ, Chen ZH, Luitel SD, et al. Advances on ultrasound-guided radial artery catheterization. Perioper Precis Med 2023;1(1):2-14.

Endnote Style：Book 

Author. Title. Place Published. Publisher, Year.

Endnote Style：Book Section/Chapter 

Author. Chapter Title. In: Editor, editors. Book Title. Place Published. Publisher, Year. p. Pages.

Endnote Style：Thesis 

Author. Title. University Year.

Endnote Style：Web page 

Title. Available at: URL

Endnote Style：Advance online publication 

Author. Title (Advance online publication). Journal Year;Volume(Issue):Pages.

Endnote Style：Preprint 

Author. Title (Preprint). Platform Year.

Endnote Style：Patent 

Author. Title. Place applied patent No. Date (2023/06/30).

Endnote Style：Conference Proceedings 

Author. Title. Volume (No.): Name of Proceedings. Publisher Year;Pages.

Endnote Style：Conference Paper 

Author. Title. Conference Name Year;Pages.

Figure legends: Figure legends must contain a brief title (bold) for the whole figure and a detailed description of each panel or part. In addition, all symbols used to indicate significant differences in the figures must be defined accordingly.

Units and Abbreviations: System International (SI) units should be used for all measurements. All abbreviations should be explicitly defined at their first occurrence, except for those internationally acceptable and should not be used unless they appear at least 3 times in the abstract or text.

Tables & Figures

All tables should be provided in the three-line table format (editable) in a Word file. Cite tables consecutively in the numerical order of their first citation in the text by Arabic numbers (Table 1, Table 2, etc.), and provide a brief title as well as notes (if any) for each.

All figures should be professionally prepared at a preferred resolution of at least 300 dpi, in jpeg or tiff format. Cite figures consecutively in the order of their first citation in the text by Arabic numbers (Figure 1, Figure 2, etc.) and provide a brief title as well as figure legends for each. Subfigures should be labeled appropriately (Figure 1A, Figure 1B, etc.) in the top left corner and described in detail, especially the statistical symbols.

Please note that supplementary tables and figures should be submitted together with tables and figures, and the Tables & Figures file (WORD, JPEG OR TIFF, and ZIP) should not exceed 50 Mb in size.

Supplementary File

Supplementary files, which are directly relevant but not essential to the conclusions of the paper, should be submitted in a separate file along with the manuscript and with all subsequent submissions.

Language editing certificate, Institutional Review Board (IRB) Approval Report or Ethics Committee Report, supplementary methods, etc. can be submitted as a supplementary file (Maximum file size: 50 Mb).

Publication Ethics Statement

Generally, Zentime follows guidance produced by bodies that include the Committee on Publication Ethics (COPE; https://publicationethics.org/), the World Association of Medical Editors (WAME; www.wame.org) and the International Committee of Medical Journal Editors (ICMJE; www.icmje.org).

Ethical Guidelines for Authors

Authors should abide by academic ethics and always make sure that

a. None of the materials in the paper have been published or are under consideration for publication elsewhere unless approved by the editors.

b. The work was designed and conducted by all the authors and the manuscript has been written, read, and approved by all the authors.

c. All data in the submitted manuscript are authentic (not fabricated or manipulated) and retrievable.

d. All the work in the submitted manuscript is original with no plagiarism. Acknowledge and cite any content reproduced from other sources (obtain permission if necessary).

e. Any conflicts of interest are clearly declared, e.g., employment, consultancy personal relationships and academic competition.

f. Research involving human participants, human materials, or human data, must have been conducted in accordance with the Declaration of Helsinki and must have been approved by an appropriate ethics committee. Research involving experimentation with human subjects or tissues must include a statement declaring that informed consent was obtained from the subjects or guardians for participation in the study or use of their tissue. Research involving experiments on animals must demonstrate whether an institution's guide, a national research council's guide, or any national law on the care and use of laboratory animals was followed. A statement including the name of the ethics committee and the reference number, and the Institutional Review Board (IRB) Approval Report or Ethics Committee Report must be provided if applicable. If a study has been granted an exemption from requiring ethics approval, this should also be detailed in the manuscript.

g. To notify the journal editor or publisher promptly if a significant error in their publication is identified and make retractions or give erratum if necessary.

h. Three potential peer reviewers with detailed contact information should be provided (if any), who are experts in their field of study and will be able to provide an objective evaluation of the manuscript.

This list is not exhaustive, and authors should be aware of local regulations and accepted norms within academic publishing society.

Ethical Guidelines for Reviewers

Reviewers are responsible for the professional review and will always

a. Accept manuscripts with rigorous standards of academic excellence.
b. Review submitted manuscripts objectively and timely.
c. Treat a manuscript received for review as a confidential document; do not use or disclose information, arguments or interpretations contained in a manuscript under review.
d. Alert the editor of any published or previously submitted content that is substantially similar to that under review.
e. Point out relevant published work that has not been cited by the authors.
f. Notify any potential conflicts of interest that may be concerned.

For general guidance on reviewing a manuscript, see information for the reviewers. The details here are related to some specific ethical issues only.

Ethical Guidelines for Editors

Editors are responsible for the whole review process and will always

a. Act in a balanced, fair and objective way without discrimination concerning sexual orientation, religious or political beliefs, gender, ethnic or geographical background of the authors. Editors have complete responsibility and authority to accept a submitted paper for publication or to reject it.
b. Be assured that there is no conflict of interest with respect to manuscripts they reject/accept.
c. Preserve the anonymity of reviewers.
d. Deal with complaints properly, ethical or otherwise, according to our general guidance.
e. Decide whether to publish an erratum or retract a manuscript directly depending on the nature and severity of the infraction.

Ethical Guidelines for Publisher

Zentime, as a responsibility Publisher, will always
a. Ensure that all articles published meet the standards and requirements listed above.
b. Ensure that any erratum, retraction, and/or clarification are published when necessary.
c. Maintain the integrity of the academic record and follow high intellectual and ethical standards.

Copyright and Licensing

For all articles published in English journals:

Articles are licensed under an open access Creative Commons CC BY 4.0 license, allowing others to download articles and share them only if they properly credit the authors and the publisher. This allows for maximum use and exposure of the work, while ensuring that the authors receive proper credit.

For all articles published in Metaverse in Medicine:

Articles are licensed under an open access Creative Commons CC BY-NC-ND 4.0 license, allowing others to download articles and share them with the authors and the publisher properly credited, but neither modifications nor commercial uses are permitted. 

If you have a specific condition that does not allow this license, please specify this to the Editorial Office of the journal on submission, and our editors will deal with it properly.

For previously published content:

Authors are responsible for obtaining permission to use material owned by others. If a figure or table has been published previously, copyright permission should be obtained before submitting the manuscript.

Please note permission is required for

a. The authors’ own work published by other publishers and for which the authors did not retain copyright.

b. Substantial extracts from other works.

c. Previously published tables, graphs, charts, schemes and artworks if they are unaltered or slightly changed.

d. Photographs which the authors do not hold the copyright.