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DOI: https://doi.org/10.61189/905466eqluyw
Endless possibilities in academia
Endless possibilities in academia
Sixu Chen1,2,5,*, Jiayin Wang3,5,*, Weiqi Lin4,5,*, Xinyi Xie3,5, Yutong Sun4,5, Haiyi Qian3,5, Yichen He1,2,5, Cuifeng Zhang1,2,5
1School of Anesthesiology, Wannan Medical College, Wuhu, Anhui Province, China. 2Anesthesia Laboratory and Training Center, Wannan Medical College, Wuhu, Anhui Province, China. 3School of Pharmacology, Wannan Medi-cal College, Wuhu, Anhui Province, China. 4School of Clinical Medicine, Wannan Medical College, Wuhu, Anhui Province, China. 5Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center, Wannan Medical College, Wuhu, Anhui Province, China.
* The authors contribute equally and co-first authors.
Address correspondence to: Cuifeng Zhang, School of Anesthesiology, Wannan Medical College, Wuhu, Anhui Province, China, No. 22 Wenchang West Road, Yijiang District, Wuhu 241002, Anhui Province, China. Tel: +86-15551257181. E-mail: zhangcuifeng@wnmc.edu.cn.
DOI: https://doi.org/10.61189/579841iexakc
Received March 5, 2025; Accepted May 12, 2025; Published December 31, 2025
Highlights
● The pathogenesis of sepsis-induced acute lung injury is outlined.
● A comprehensive overview of the role of TCM extracts in sepsis-induced acute lung injury is provided.
● The clinical application of classical TCM extracts is summarized in detail.
Review Article |Published on: 31 December 2025
[Perioperative Precision Medicine] 2025; 3 (4): 122-133
Jiaxun Jiang1, Miao Zhou2, Liangqing Lin3, Haipo Cui1, Long Liu1, Jiaen Wu1, Zhaopeng Zhou1
1School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. 2Jiangsu Cancer Hospital, Nanjing 213164, Jiangsu Province, China. 3Anesthesiology, The First Hospital of Putian, Putian 351100, Fujian Province, China.
Address correspondence to: Haipo Cui, School of Health Science and Engineering, University of Shanghai for Science and Technology, No. 516 Jungong Road, Yangpu District, Shanghai 200093, China. E-mail: h_b_cui@163.com.
DOI: https://doi.org/10.61189/295165xbmhth
Received April 1, 2025; Accepted May 12, 2025; Published December 31, 2025
Highlights
● Deep learning-powered nerve block segmentation significantly contributes to optimized perioperative pain management by enhancing the precision and safety of regional anesthesia.
● Advanced architectures, particularly U-Net variants, dominate peripheral nerve block segmentation, offering high precision and adaptability to medical imaging challenges.
● Deep learning enhances clinical workflows by improving segmentation accuracy and efficiency in upper and lower limb nerve blocks, thereby supporting procedural success.
● Future efforts will focus on improving model robustness and generalizability to address limitations such as data variability and limited adaptability, facilitating broader clinical adoption.
Review Article |Published on: 31 December 2025
[Perioperative Precision Medicine] 2025; 3 (4): 134-151
Huan Li1,2, Xiaoyu Tang1,2, Jiameng Liu1,2, Wanning Li1,2, Xin Niu1,2, Xingchen Yue1,2, Shangping Fang1,2
1School of Anesthesiology, Wannan Medical College, Wuhu 241002, Anhui Province, China. 2Anesthesia Laboratory and Training Center, Wannan Medical College, Wuhu 241002, Anhui Province, China.
Address correspondence to: Shangping Fang, Anaesthesiology Experimental Training Center, College of Anesthesiology, Wannan Medical College, No. 22 Wenchang West Road, Yijiang District, Wuhu 241002, Anhui Province, China. Tel: +86-19855362767. E-mail: fangshangping0@163.com.
Acknowledgement: This work was supported by Key Project Research Fund of Wannan Medical College (WK2022Z10); Anhui Province College Student Innovation and Entrepreneurship Training Program Project (S202410368031); Anhui Province College Student Innovation Training Program Project (S202510368032).
DOI: https://doi.org/10.61189/167468gjipte
Received April 15, 2025; Accepted July 25, 2025; Published December 31, 2025
Highlights
● This review focuses on the research of bone marrow mesenchymal stem cells (BM-MSCs) in treating acute liver failure (ALF).
● BM-MSCs are a heterogeneous subset of stromal stem cells that can be isolated from various adult tissues.
● BM-MSCs have the ability to migrate toward damaged tissues and differentiate into hepatocytes. They effectively suppress pro-inflammatory cytokine release and promote hepatocyte proliferation.
● BM-MSCs are a promising target for clinical treatment of acute liver failure.
● BM-MSCs provide a new therapeutic direction for patients with acute liver failure during the perioperative period.
Review Article |Published on: 31 December 2025
[Perioperative Precision Medicine] 2025; 3 (4): 168-175
Jiayin Wang1,4,5,*, Sixu Chen2,5,*, Weiqi Lin3,4,*, Xinyi Xie1,5, Yutong Sun3,5, Qin Zhang3,5, Qixiang Xu1,4,5, Cuifeng Zhang2,5
1School of Pharmacology, Wannan Medical College, Wuhu, Anhui, China. 2School of Anesthesiology, Wannan Medical College, Wuhu, Anhui, China. 3School of Clinical Medicine, Wannan Medical College, Wuhu, Anhui, China. 4Anesthesia Laboratory and Training Center, Wannan Medical College, Wuhu, Anhui, China. 5Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center, Wannan Medical College, Wuhu, Anhui, China.
* The authors contribute equally and co-first authors.
Address correspondence to: Qixiang Xu, School of Pharmacology, Wannan Medical College, No. 22 Wenchang West Road, Yijiang District, Wuhu 241002, Anhui, China. Tel: +86-18355305112. E-mail: xuqixiang@wnmc.edu.cn. Cuifeng Zhang, School of Anesthesiology, Wannan Medical College, No. 22 Wenchang West Road, Yijiang District, Wuhu 241002, Anhui, China. Tel: +86-15551257181. E-mail: zhangcuifeng@wnmc.edu.cn.
Acknowledgement: This work was supported by The Foundation of Wannan Medical College (WK2023ZQNZ08), National university innovation and entrepreneurship training program (202310368014, 202310368049, 202410368014), Anhui Province university innovation and entrepreneurship training program (S202310368095, S202310368087, S202410368004, S202410368009).
DOI: https://doi.org/10.61189/691939hefazb
Received March 2, 2025; Accepted June 4, 2025; Published December 31, 2025
Highlights
● A comprehensive review of the role of ferroptosis in sepsis-induced myocardial injury is presented.
● The mechanisms of ferroptosis and recent advancements in its involvement in sepsis-induced myocardial injury are discussed.
● Perioperative whole-process risks may induce sepsis, activate ferroptosis and raise myocardial injury risk, while integrating ferroptosis into management can reduce this risk.
Review Article |Published on: 31 December 2025
[Perioperative Precision Medicine] 2025; 3 (4): 176-185
Jiaen Wu1, Jiaxun Jiang1, Zhaopeng Zhou1, Miao Zhou2, Liangqing Lin3, Jinjing Wu1, Haipo Cui1
1School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. 2Jiangsu Cancer Hospital, Changzhou 213164, Jiangsu Province, China. 3Department of Anesthesiology, The First Hospital of Putian, Putian 351100, Fujian, China.
Address correspondence to: Haipo Cui, School of Health Science and Engineering, University of Shanghai for Science and Technology, No. 516 Jungong Road, Yangpu District, Shanghai 200093, China. E-mail: h_b_cui@163.com.
DOI: https://doi.org/10.61189/251934gxqfic
Received April 9, 2025; Accepted August 13, 2025; Published December 31, 2025
Highlights
● This study compares deep learning methods for brachial plexus ultrasound segmentation, demonstrating improved segmentation efficiency and reduced learning difficulty, which may enhance perioperative regional anesthesia planning and safety.
● U-Net is favored for brachial plexus segmentation due to its enhanced ability to capture contextual features through increased channel utilization.
● Available public brachial plexus datasets are summarized, offering valuable resources for future research and perioperative ultrasound applications.
Review Article |Published on: 31 December 2025
[Perioperative Precision Medicine] 2025; 3 (4): 186-199
Sen Lu, Xiangbing Shui, Jianxin Zhang
Department of Anesthesiology, Suzhou BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Suzhou 215010, Jiangsu Province, China.
Address correspondence to: Sen Lu, Department of Anesthesiology, Suzhou BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, No. 181 Zhuyuan Road, Suzhou 215010, Jiangsu Province, China. E-mail: Sen.Lu@benqmedicalcenter.com.
Acknowledgement: This work was supported by the Suzhou BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University (SZMJ2209). The authors would like to thank all the guest editors and anonymous reviewers for their constructive comments.
DOI: https://doi.org/10.61189/924159jtzdps
Received July 7, 2025; Accepted December 4, 2025; Published December 31, 2025
Highlights
● Explored the delivery analgesia mode for the special population of first-time mothers with severe pain.
● Explored the effectiveness and safety of high-concentration ropivacaine in epidural labor analgesia.
● Focused on providing humanistic care for the emotional well-being of postpartum women, extending beyond mere pain relief.
Research Article |Published on: 31 December 2025
[Perioperative Precision Medicine] 2025; 3 (4): 200-206
Weiqi Lin1,2,3*, Qin Zhang1,3* , Sixu Chen2,4*, Xinyi Xie3,5 , Jiayin Wang3,5, Yutong Sun1,3, Qixiang Xu3,5, Cuifeng Zhang2,3,4
1School of Clinical Medicine, Wannan Medical College, Wuhu 241002, Anhui, China. 2Anesthesia Laboratory and Training Center, Wannan Medical College, Wuhu 241002, Anhui, China. 3Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center, Wannan Medical College, Wuhu 241002, Anhui, China. 4School of Anesthesiology, Wannan Medical College, Wuhu 241002, Anhui, China. 5School of Pharmacology, Wannan Medical College, Wuhu 241002, Anhui, China.
*The authors contribute equally.
Address correspondence to: Qixiang Xu, School of Pharmacology, Wannan Medical College, No.22 Wenchang West Road, Yijiang District, Wuhu 241002, Anhui Province, China. Tel: +86-18355305112. E-mail: xuqixiang@wnmc.edu.cn. Cuifeng Zhang, School of Anesthesiology, Wannan Medical College, No.22 Wenchang West Road, Yijiang District, Wuhu 241002, Anhui Province, China. Tel: +86-15551257181. E-mail: zhangcuifeng@wnmc.edu.cn.
Acknowledgement: This work was supported by the Natural Science Foundation Of The Higher Education Insti tutions Of Anhui Province (2024AH051958), the Foundation Of Wannan Medical College (WK2023ZQNZ08), the National University Innovation And Entrepreneurship Training Program (202310368014, 202310368049, 202410368014), the Anhui Province University Innovation And Entrepreneurship Training Program (S202310368087, S202410368004, S202410368009), the Wannan Medical College Undergraduate Research Fund Project (WK2024XS01).
DOI: https://doi.org/10.61189/313450skrqzv
Received January 21, 2025; Accepted April 24, 2025; Published December 31, 2025
Highlights
● Cycloastragenol exhibits anti-aging, anti-cancer, and anti-fibrosis effects.
● Although cycloastragenol shows innovative therapeutic potential, further clinical trials are essential to confirm its clinical applicability.
● Cycloastragenol offers innovative therapeutic avenues for enhancing surgical recovery.
Review Article |Published on: 31 December 2025
[Perioperative Precision Medicine] 2025; 3 (4): 207-215
Chenglong Zhu1, Wenyun Xu1,2, Zui Zou1
1School of Anesthesiology, Naval Medical University, Shanghai 200433, China. 2Department of Anesthesiology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China.
Address correspondence to: Zui Zou, School of Anesthesiology, Naval Medical University, 168 Changhai Road, Yangpu District, Shanghai 200433, China. E-mail: zouzui@smmu.edu.cn.
DOI: https://doi.org/10.61189/156428jxplrz
Received October 26, 2024; Accepted January 7, 2025; Published September 30, 2025
Many patients, such as those who are obese, are prone to hypoxia during anaesthesia induction, painless gastroenteroscopy, and ICU sedation, which can lead to severe organ damage [1]. The traditional nasopharyngeal airway can effectively alleviate this problem, but it also introduces complications such as epistaxis [2]. NaPSflex (Nasal Pharyngeal Set-flexible) is a novel nasopharyngeal airway set developed by our team, designed to address difficult airways safely and simply. It has been registered as a medical device in China (Zhejiang Medical Device Registration Approval No. 20232081212).
NaPSflex consists of a reinforced catheter, a spring core, a restrictive nose plug, and an adapter (Figure 1). The reinforced catheter has small holes underneath for ventilation. With an outer diameter of only 4 mm, it prevents nasopharyngeal compression damage during catheter retention. The catheter is made of a flexible material to reduce the risk of nasal mucosa abrasion. The spring core is flexible, allowing easy access to the nasopharyngeal lumen. The restrictive nose plug regulates the catheter’s depth into the nasal cavity and helps secure it in place. Additionally, the catheter can be connected to either a nasal cannula or an anaesthesia machine’s breathing line via the adapter for oxygenation.
Several randomized controlled studies, approved by the Ethics Committee of the Naval Medical University and currently in the process of data collection, may provide robust evidence of its safety and efficacy. We believe that the new nasopharyngeal airway set can be widely adopted by anesthesiologists due to its potential in airway management.
Letter to the Editor |Published on: 30 September 2025
[Perioperative Precision Medicine] 2025; 3 (3): 71
Rahul Kumar Chaudhary, Prajwal Bista*, Lalit Kumar Rajbanshi*, Kanak Khanal*
Department of Anesthesiology and Critical Care, Birat Medical College Teaching Hospital, Morang, 56613, Nepal.
*The authors contribute equally.
Address correspondence to: Rahul Kumar Chaudhary, Department of Anesthesiology and Critical Care, Birat Medical College Teaching Hospital, Tankisinuwari, Dharan Road, Morang, 56613, Nepal. E-mail: rahulkr9991@gmail.com.
DOI: https://doi.org/10.61189/655401cvkjpp
Received June 24, 2025; Accepted August 29, 2025; Published September 30, 2025
Highlights
● Anaphylaxis is a potentially life-threatening event during general anesthesia, with a rare incidence estimated at 1 in 10,000 to 1 in 20,000 cases.
● Neuromuscular blocking agents, antibiotics, and latex are the primary triggers of perioperative anaphylaxis, with rocuronium being one of the most commonly implicated drugs.
● Sugammadex is a valuable drug for reversing rocuronium-induced refractory anaphylaxis.
Case report |Published on: 30 September 2025
[Perioperative Precision Medicine] 2025; 3 (3): 72-75.
Yu Xiang, Jiameng Liu, Huan Li, Kecheng Zhai, Xingchen Yue, Shangping Fang
Anesthesia Laboratory and Training Center, School of Anesthesiology, Wannan Medical College, Wuhu 241002, Anhui Province, China.
Address correspondence to: Shangping Fang, Anesthesia Laboratory and Training Center, School of Anesthesiology, Wannan Medical College, No.22, Wenchang West Road, Lugang Street, Yijiang Dis trict, Wuhu 241002, Anhui Province, China. Tel: +86-19855362767; E-mail: 20180041@wnmc.edc. cn.
Acknowledgement: This work was supported by Anhui Province College Student Innovation and Entrepreneurship Project (S202310368027 and S202410368031).
DOI: https://doi.org/10.61189/843291jljiwm
Received December 12, 2024; Accepted February 14, 2025; Published September 30, 2025
Highlights
●Lipid metabolism and iron metabolism pathways are key biological pathways involved in ferroptosis.
● Ferroptosis exhibits complex crosstalk with other cell death forms in sepsis, with significant implications for dis ease pathogenesis and therapy.
● Ferroptosis plays a critical role in sepsis-related organ damage and prognosis.
● This review suggests directions and perspectives for treating ferroptosis and sepsis in the perioperative period.
Review Article |Published on: 30 September 2025
[Perioperative Precision Medicine] 2025; 3 (3): 105-115.
Chenglong Zhu1, Jianhua Xia2, Zui Zou1
1School of Anesthesiology, Naval Medical University, Shanghai 200433, China. 2Department of Anesthesiology, Shanghai Pudong New Area People's Hospital, Shanghai 201200, China.
Address correspondence to: Zui Zou, School of Anesthesiology, Naval Medical University, 168 Changhai Road, Yangpu District, Shanghai 200433, China. E-mail: zouzui@smmu.edu.cn.
DOI: https://doi.org/10.61189/905466eqluyw
Received October 26, 2024; Accepted January 7, 2025; Published June 30, 2025
Difficult airways are a common concern for physicians in the department of anesthesiology, emergency medicine, and critical care medicine. SEEKflex (Safe Easy Endotracheal kit-flexible) is a novel multifunctional introducer developed by our team to address difficult airways. It has been registered as a medical device in China (Zhejiang Medical Device Registration Approval No. 20232081322).
The SEEKflex system features a dual-component design, consisting of a primary introducer and a supplementary adapter. With an outer diameter of 4.0 mm and an inner diameter of 2.4 mm, it is compatible with tracheal tubes of an internal diameter exceeding 4.5 mm. The introducer, extending from 43 to 81 cm, is equipped with a flexible steel core for guidance and a smooth polyvinyl chloride (PVC) sheath. This assembly can be securely fastened using a blue locking mechanism, as depicted in Figure 1A-B [1].
SEEKflex can be bent at an appropriate angle due to the malleability of its inner core, allowing it to be easily inserted into the trachea just under the epiglottis in cases of unpredicted difficult airway (Cormack-Lehane Grade III). This procedure is facilitated by a video laryngoscope. The endotracheal position of SEEKflex is confirmed by connecting it to an EtCO2 monitor via the adapter after removing the inner core (Figure 1C). The endotracheal tube can be easily advanced into the trachea using the Seldinger technique, with the guidance of reconnected, post-stretching SEEKflex. In addition, we have developed a "12-step" approach for awake tracheal intubation using SEEKflex and a video laryngoscope, which has yielded satisfactory clinical results [2].
At the distal end of the outer catheter, there is one vent at the top and 4 rows of lateral vents. After removing the inner core and attaching the adapter, local anesthetic can be administrated, and oxygenation can be maintained using a ventilator, like a slender tracheal tube. The original version of this introducer was used for reintubation of COVID-19 patients, and the outer catheter could be left in place for subglottic oxygenation after extubation [3]. This feature is also used for oxygenation maintenance and tracheal intubation in emergency situations during bronchoscopic balloon dilation [4].
Several randomized controlled studies, approved by the Ethics Committee of the Naval Medical University and currently in the process of data collection, may further provide robust evidence of its safety and efficacy. We believe that this new multifunctional introducer can be widely adopted by anesthesiologists due to its versatility across multiple clinical scenarios.
Letter to the Editor |Published on: 30 June 2025
[Perioperative Precision Medicine] 2025; 3 (2): 39-40
Tian Zhou1, Chenglong Zhu1, Feixiang Wu2, Xingzhi Liao3, Wenyun Xu4, Hui Chen5, Jinlong Qu6, Jinfei Shi7, Yaohua Yu8, Ying Huang9, Miao Zhou10, Hua Tang11, Shengyun Cai12, Wenchao Gao13, Zui Zou1
1School of Anesthesiology, Naval Medical University, Shanghai, 200433, China. 2Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China. 3Department of Anesthesiology, The 904th Hospital of the Logistics Support Force of the Chinese People's Liberation Army, Wuxi 214044, Jiangsu Province, China. 4Department of Anesthesiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China. 5Department of Anesthesiology and Perioperative medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China. 6Department of Emergency and Critical Care Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China. 7Department of Anesthesiology, Anhui Provincial Hospital of the Armed Police, Hefei 230001, Anhui Province, China. 8Department of Anesthesiology, The First Hospital of Putian City, Putian 351100, Fujian Province, China. 9Department of Intensive Care Unit, the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, China. 10Department of Anesthesiology, the Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University, Nanjing 210009, Jiangsu Province, China. 11Department of Thoracic Surgery, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China. 12Department of Obstetrics and Gynecology, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China. 13Department of Colorectal Surgery, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.
Address correspondence to: Shengyun Cai, Department of Obstetrics and Gynecology, First Affiliated Hospital of Naval Medical University, 168 Changhai Road, Shanghai 200433, China. Email: caicai24@126.com. Wenchao Gao, Department of Colorectal Surgery, Second Affiliated Hospital of Naval Medical University, 415 Fengyang Road, Shanghai 200003, China. Email: gaowenchao2007@163.com. Zui Zou, School of Anesthesiology, Naval Medical University, 168 Changhai Road, Shanghai 200433, China. Email: zouzui@smmu.edu.cn.
Acknowledgement: This study was funded by the following projects: Shanghai Industrial Collaborative Innovation Project (HCXBCY - 2023 – 041, XTCX - KJ - 2024 - 39, HCXBCY - 2024 – 033), 2024 Basic Medicine Innovation Open Topic (JCKFKT - MS - 002), and the 2024 Annual Pharmaceutical Science and Technology Key Research Project of the China Medicine Education Association (2024KTZ011).
DOI: https://doi.org/10.61189/707615erclry
Received February 20, 2025; Accepted February 24, 2025; Published June 30, 2025
Expert Consensus |Published on: 30 June 2025
[Perioperative Precision Medicine] 2025; 3 (2): 41-47
Mingling Wang1, Lien Qi1, Kai Wang2, Jing Zhang3, Xiaoyan Wang1
Departments of 1Operating Room, 2Anesthesiology, 3Nursing, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu Province, China.
Address correspondence to: Xiaoyan Wang, Department of Operating Room, Xuzhou Central Hospital, Jiefang South Road, No. 199, Xuzhou 221009, Jiangsu Province, China. Tel: +86-15351687352; E-mail: 531446635@qq.com; Jing Zhang, Department of Nursing, Xuzhou Central Hospital, Jiefang South Road, No. 199, Xuzhou 221009, Jiangsu Province, China. Tel: +86-18012018586; E-mail: 2038634928@qq.com.
Ethics approval and consent to participate: The study protocol was approved by the Institutional Review Committee of Xuzhou Central Hospital (approval no. XZXY-LK-20220114-027) and conducted in accordance with the ethical principles for medical research involving human subjects described in the Declaration of Helsinki. Prior to inclusion in this study, informed consent was obtained from all participants. Trial Registration clinicaltrials.gov Identifier: CTR20200708.
DOI: https://doi.org/10.61189/082747tokokd
Received July 8, 2024; Accepted September 3, 2024; Published June 30, 2025
Highlights
● Gastrointestinal decompression (GID) near the gastric body reduces nausea, vomiting, and discomfort.
● GID near the gastric body is conducive to exposure of the operative space.
● GID near the gastric body improves postoperative recovery of gastrointestinal function.
Research Article |Published on: 30 June 2025
[Perioperative Precision Medicine] 2025; 3 (2): 48-53
Wenxin Shi, Yajun Hu, Jin Lan, Jun Xiong, Zhiyong Li
Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Shanghai 200082, China.
Address correspondence to: Jun Xiong, Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Xiangyin Road, Yangpu District, Shanghai 200082, China. E-mail: xiongjun2001@163.com; Zhiyong Li, Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Xiangyin Road, Yangpu District, Shanghai 200082, China. E-mail: zhiyongli@smmu.edu.cn.
Acknowledgement: This work was supported by grants from the Shanghai Science (23ZR1477400) and Technology Commission Project (201409004600).
DOI: https://doi.org/10.61189/629158xrbqam
Received October 28, 2024; Accepted January 7, 2025; Published June 30, 2025
Highlights
● Intestinal barrier dysfunction increases the risk of perioperative complications.
● The immunologic barrier is crucial for maintaining intestinal homeostasis.
● Perioperative factors compromise the intestinal immunologic barrier, increasing infection risk.
● An imbalance between intestinal microbiota and immune cells affects postoperative recovery.
● Clinical intervention studies targeting the intestinal barrier are summarized.
Review Article |Published on: 30 June 2025
[Perioperative Precision Medicine] 2025; 3 (2): 54-70
