Research progress of the biological clock gene in pancreatic cancer-ZENTIME PUBLISHING CORPORATION LIMITED

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Research progress of the biological clock gene in pancreatic cancer

Haoran Huang¹ , Ge Yu² , Rong Wan^1,2*

¹University of Shanghai for Science and Technology, Shanghai 200093, China. ²Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China.

Address correspondence to: Rong Wan, Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Hongkou District, Shanghai 200080, China. E-mail: rong.wan@shgh.cn.

Received May 20, 2025; Accepted August 4, 2025; Published December 31, 2025

DOI: https://doi.org/10.61189/214925rzkcoo

Highlights

● Biological clock genes play a crucial roles in pancreatic cancer progression.

● Abnormal expression of biological clock genes is closely associated with malignant proliferation, invasion, me- tastasis, and resistance to chemotherapy.

● Multiple biological clock genes promote pancreatic cancer progression by modulating key signaling pathways.

Abstract

Biological clock genes, which regulate the body’s circadian rhythm, play a crucial role in pancreatic cancer development. The abnormal expression of these genes is closely associated with malignant proliferation, invasion, metastasis, and resistance to chemotherapy. Several biological clock genes in pancreatic cancer tissues contribute to tumor progression by modulating key signaling pathways. Moreover, disruptions in circadian clock genes are significantly linked to poor prognosis and may serve as diagnostic markers and prognostic indicators. This review summarizes recent research on the regulatory mechanisms of biological clock genes in pancreatic cancer, emphasizing their potential clinical applications as diagnostic markers, therapeutic targets, and prognostic tools. These findings may lead to new approaches for personalized pancreatic cancer treatment.

Keywords: Biological clock genes, pancreatic cancer; biomarkers, therapeutic targets

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