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Perioperative Precision Medicine
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Search Result (320)
Perioperative Precision Medicine
Case Report
Open Access
Anesthetic management of elderly hip fracture patients with severe cardiac disease: A report of four cases and the application of ultrasound techniques
Liangqing Lin
Liangqing Lin
Department of Anesthesiology, The First Hospital of Putian, Putian 351100, Fujian, China.
,
Qinghua Wu
Qinghua Wu
Department of Anesthesiology, The First Hospital of Putian, Putian 351100, Fujian, China.
,
Pinhui Ke
Pinhui Ke
Department of Anesthesiology, The First Hospital of Putian, Putian 351100, Fujian, China.
,
Chunlan Lin
Chunlan Lin
Department of Anesthesiology, The First Hospital of Putian, Putian 351100, Fujian, China.
,
Shuantong Lin
Shuantong Lin
Department of Anesthesiology, Eastern Bund Healthcare, Shanghai 202162, China.
,
Yaohua Yu
Yaohua Yu
yyh.8@163.com
Department of Anesthesiology, The First Hospital of Putian, Putian 351100, Fujian, China.
2026 Sep;4(3):306-312
https://doi.org/10.61189/854764zlpjls
Article Preview PDF CITE
Lin LQ, Wu QH, Ke PH, Lin CL, Lin ST, Yu YH. Anesthetic management of elderly hip fracture patients with severe cardiac disease: A report of four cases and the application of ultrasound techniques. Perioper Precis Med. 2026 Sep; 4 (3): 306-312. doi: 10.61189/854764zlpjls
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This report describes the anesthetic management of four elderly patients with hip fractures complicated by different types of severe cardiac disease, including severe mitral stenosis, post–myocardial infarction status, severe pulmonary hypertension, and acute exacerbation of chronic heart failure. All patients underwent individualized, ultrasound-guided precision anesthesia strategies, incorporating ultrasound-guided vascular access, nerve blocks, neuraxial anesthesia, and dynamic perioperative assessment using transthoracic echocardiography. Management followed a pathophysiology-oriented approach, emphasizing multimodal analgesia and multidisciplinary collaboration. All four patients completed the perioperative period uneventfully. This report aims to explore individualized anesthetic strategies for extremely high-risk patients in the era of visualization-based medicine.

Progress in Medical Devices
Research Article
Open Access
Simulation based on temporal interference of transcutaneous peripheral nerve stimulation for Parkinson’s disease
Zhiyuan Zhao
Zhiyuan Zhao
Shanghai Institute for Minimally Invasive Therapy, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Wenjie Yu
Wenjie Yu
Shanghai Institute for Minimally Invasive Therapy, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Chengli Song
Chengli Song
csong@usst.edu.cn
Shanghai Institute for Minimally Invasive Therapy, University of Shanghai for Science and Technology, Shanghai 200093, China.
2026 Sep;4(3):245-255
https://doi.org/10.61189/229030kwzevg
Article Preview PDF CITE
Zhao ZY, Yu WJ, Song CL. Simulation based on temporal interference of transcutaneous peripheral nerve stimulation for Parkinson’s disease. Prog Med Devices. 2026 Jul; 4 (3): 245-255. doi: 10.61189/229030kwzevg
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Objective: The aim was to assess how the spatial resolution and the targeting capability of peripheral electrical stimulation influence the treatment of resting tremors in Parkinson’s disease (PD). Methods: Firstly, NEURON 8.0 and the Hodgkin-Huxley model were used to analyze the low-frequency properties of neurons. Then, a simplified three-layer human model was developed in COMSOL Multiphysics to examine how different frequency currents penetrate biological tissues. Additionally, a two-dimensional temporal interference model was used to study how the electrode configuration affects the interference area. Results: The simulations clearly showed that the interference electric field goes deep under the skin and soft tissues, thus generating stable interference signals. Furthermore, the validation of the experiments indicated that the generated interference electric stimulation signals were stable and their parameters were reproducible. Hence, this technology allows non-invasive deep control of the nervous system via peripheral nerve pathways, thus avoiding surgical risks, which is a step forward in comparison with existing methods. Conclusion: By using the physical principle of “external carrier-internal interference”, this work has come up with a novel non-invasive way for PD tremor treatment which solves the problem of spatial limitations of conventional electrical stimulation. Also, the parameter optimization and simulation results provide a great level of technical support for the development of closed-loop devices for PD treatment.
Perioperative Precision Medicine
Perspective
Open Access
Rapid anesthesia assessment and clinical emergency management in emergency surgery
Songxiao Yang
Songxiao Yang
Department of Radiation Oncology, The First Affiliated Hospital of Hainan Medical University, Haikou 570100, Hainan, China.
,
Ping Zhou
Ping Zhou
ping.zhou@muhn.edu.cn
Radiotherapy Department II, Key Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital, The First Clinical College, Hainan Medical University, Haikou 570100, Hainan, China.
2026 Mar;4(1):62-66
https://doi.org/10.61189/891717grkkpo
Article Preview PDF CITE

Yang SX, Zhou P. Rapid anesthesia assessment and clinical emergency management in emergency surgery. Perioper Precis Med. 2026 Mar; 4 (1): 62-66. doi: 10.61189/891717grkkpo

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Supplementary File Article Preview

Emergency surgery anesthesia is performed in an extremely time-critical and high-risk setting, where delayed or inaccurate assessment may lead to severe perioperative complications. Patients often present with hemodynamic instability, limited preoperative information, and complex comorbidities, creating major challenges for anesthesiologists to rapidly evaluate airway, circulation, and physiological reserve. Although multiple assessment tools exist, conventional approaches remain fragmented and insufficient for dynamic, real-time decision-making in emergency contexts. There is a clear need for an integrated rapid anesthesia assessment framework that combines advanced monitoring, intelligent decision support, and team-based coordination. This perspective article systematically analyzes rapid assessment models that integrate multimodal point-of-care ultrasound, artificial intelligence–assisted regulation, and closed-loop clinical decision support system (CDSS) protocols. Key applications in perioperative airway management, hemodynamic and respiratory assessment, and risk stratification for special populations, including elderly and pediatric patients, are discussed. We further summarize the rapid titration and hemodynamic advantages of novel anesthetic agents in emergency induction, the role of CDSS and closed-loop communication in clinical emergency management, and the optimization of team collaboration using standardized tools such as Situation–Background–Assessment–Recommendation. Ethical and legal considerations, including informed consent, presumed consent, and proxy decision-making in time-sensitive scenarios, are also addressed. Overall, integrated rapid assessment strategies supported by technology, interdisciplinary teamwork, and ethical safeguards may substantially enhance the safety, efficiency, and clinical outcomes of anesthesia management in emergency surgery, providing a practical framework for future perioperative practice and multicenter validation.

Perioperative Precision Medicine
Review Article
Open Access
Research progress of frontier image processing in medical endoscopes
Jinjing Wu
Jinjing Wu
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Yang Yuan
Yang Yuan
School of Computer Science and Artificial Intelligence, Changzhou University, Jiangsu 213164, China.
,
Long Liu
Long Liu
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Haipo Cui
Haipo Cui
h_b_cui@163.com
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Tianying Xu
Tianying Xu
School of Anesthesiology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
,
Miao Zhou
Miao Zhou
Department of Anesthesiology, the Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University, Nanjing 210009, Jiangsu, China.
,
Zhanheng Chen
Zhanheng Chen
chenzhanheng17@mails.ucas.ac.cn
School of Anesthesiology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
,
Bing Xu
Bing Xu
mzxubing1992@163.com
School of Anesthesiology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
2023 Sept;1(2):62-77
https://doi.org/10.61189/663074tcakcn
Article Preview PDF CITE

Wu JJ, Yuan Y, Liu L, et al. Research progress of frontier image processing in medical endoscopes. Perioper Precis Med. 2023 Sept;1(2):62-77. doi: 10.61189/663074tcakcn.

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In the modern medical diagnosis, digital medical images can provide physicians with a more accurate, visualized, and three-dimensional view of various tissues. These images assist in predicting, diagnosing, and treating diseases. However, medical images are highly susceptible to noise contamination from the influence of imaging equipment and the capture process, which poses a significant challenge in the analysis of medical images. This review summarizes the image processing technologies applied in endoscopy, such as image denoising, image deblurring, image enhancement, and image segmentation, involving traditional computational models and deep learning algorithms used in these technologies. Additionally, the clinical applications of these techniques are also discussed.
Perioperative Precision Medicine
Review Article
Open Access
Research progress of sphingosine 1-phosphate receptor 3 in the cardiovascular system
Yangmengna Gao
Yangmengna Gao
School of Anesthesiology, Wannan Medical College, Wuhu 241002, Anhui, China; Anesthesia Laboratory and Training Center, Wannan Medical College, Wuhu 241002, Anhui, China.
,
Ran Yuan
Ran Yuan
School of Anesthesiology, Wannan Medical College, Wuhu 241002, Anhui, China; Anesthesia Laboratory and Training Center, Wannan Medical College, Wuhu 241002, Anhui, China.
,
Kecheng Zhai
Kecheng Zhai
School of Anesthesiology, Wannan Medical College, Wuhu 241002, Anhui, China; Anesthesia Laboratory and Training Center, Wannan Medical College, Wuhu 241002, Anhui, China.
,
Hui Su
Hui Su
School of Anesthesiology, Wannan Medical College, Wuhu 241002, Anhui, China; Anesthesia Laboratory and Training Center, Wannan Medical College, Wuhu 241002, Anhui, China.
,
Renke Sun
Renke Sun
School of Anesthesiology, Wannan Medical College, Wuhu 241002, Anhui, China; Anesthesia Laboratory and Training Center, Wannan Medical College, Wuhu 241002, Anhui, China.
,
Shangping Fang
Shangping Fang
20180041@wnmc.edu.cn
School of Anesthesiology, Wannan Medical College, Wuhu 241002, Anhui, China; Anesthesia Laboratory and Training Center, Wannan Medical College, Wuhu 241002, Anhui, China.
2024 Jun;2(2):64-72
https://doi.org/10.61189/076009mwdtns
Article Preview PDF CITE
Gao YMN, Yuan R, Zhai KC, et al. Research progress of sphingosine 1-phosphate receptor 3 in the cardiovascular system. Perioper Precis Med. 2024 Jun;2(2):64-72. doi: 10.61189/076009mwdtns. 
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Sphingosine 1-phosphate receptor 3 (S1PR3) is one of the five receptors of sphingosine 1-phosphate, actively participating in physiological processes such as angiogenesis and endothelial cell differentiation. Widely expressed in various tissue cells such as muscle cells, immune cells, lymphocytes, endothelial cells, and fibroblasts, S1PR3 has garnered increasing attention in research, showcasing its involvement in various pathophysiological processes and its important role in the body’s inflammatory and immune responses. In the cardiovascular system, S1PR3 is involved in many pathophysiological processes, including angiogenesis, maintaining vascular permeability, lymphocyte transport, and physiological function of the heart. Moreover, it also plays a regulatory role in the treatment of cardiovascular diseases, such as heart ischemia/reperfusion, atherosclerosis, and cardiac fibrosis. S1PR3 also plays a crucial role in evaluation and treatment during the cardiovascular system in perioperative period and has a powerful therapeutic effect in sepsis. Regulators related to S1PR3 exhibit therapeutic potential in clinical treatments of cardiovascular diseases. This article aims to explore the role and research progress of S1PR3 in the cardiovascular system.
Progress in Medical Devices
Review Article
Open Access
Research progress on biliary stents
Qi Zhang
Qi Zhang
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Haipo Cui
Haipo Cui
h_b_cui@163.com
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Yan Zhang
Yan Zhang
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Hexuan Jiang
Hexuan Jiang
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
2023 Sept;1(2):65-74
https://doi.org/10.61189/031576vfjfax
Article Preview PDF CITE

Zhang Q, Cui HP, Zhang Y, et al. Research progress on biliary stents. Prog Med Devices. 2023 Sept;1(2):65-74. doi: 10.61189/031576vfjfax.

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Bile duct stenosis is a common condition in gastroenterology and hepatobiliary surgery and can be divided into benign stenosis and malignant stenosis according to different etiologies. The implantation of a gall stent into the site of the stenosis or obstruction is currently an important means of treating the bile duct stenosis. Biliary stents encompass two main types: plastic stents and metal stents. In recent years, biodegradable biliary stents and drug-eluting stents have also emerged. The material and structure of biliary stents have an important influence on their performance. In this paper, the research progress on biliary stent implantation technology in the treatment of biliary stenosis is reviewed. Besides, the advantages and disadvantages of biliary stents made from different materials and structures, along with their respective indications are summarized, and the development trend of degradable biliary stents is prospected.

Progress in Medical Devices
Review Article
Open Access
Research progress on intestinal anastomosis technology and related devices
Yilong Chen
Yilong Chen
Shanghai Institute for Minimally Invasive Therapy, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Lin Mao
Lin Mao
linmao@usst.edu.cn
Shanghai Institute for Minimally Invasive Therapy, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Zijie Zhou
Zijie Zhou
Shanghai Institute for Minimally Invasive Therapy, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Chengli Song
Chengli Song
Shanghai Institute for Minimally Invasive Therapy, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
2025 Mar;3(1):66-76
https://doi.org/10.61189/314845qnicsc
Article Preview PDF CITE

Yilong Chen, Lin Mao, Zijie Zhou, Chengli Song. Research progress on intestinal anastomosis technology and related devices. Prog Med Devices 2025 Mar; 3(1) : 66-76. doi: 10.61189/314845qnicsc

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This review comprehensively examines current intestinal anastomosis techniques. Traditional manual suturing methods, including intermittent and continuous sutures, provide high flexibility but but vary in infection risk and operation time. Continuous suturing is particularly effective in reducing operative time and infection risk. Suture materials include non-absorbable sutures, absorbable sutures, and natural materials, with absorbable sutures the most preferred for intestinal anastomosis. Mechanical anastomosis has gained widespread adoption, featuring both linear and circular metal staplers. Linear staplers are simple to operate, while circular staplers better align with physiological structures. Materials used in staplers include non-degradable metals (e.g., titanium, titanium alloy) and biodegradable anastomosis (e.g., magnesium alloy). Metal nail anastomosis often results in fewer complications than manual suturing in specific surgeries. Magnetic pressure anastomosis, relying on magnet attraction, has been successfully applied in clinical scenarios following extensive research. The adhesive-based approach involves medical adhesives such as cyanoacrylate and fibrin glue, offering auxiliary support for anastomosis. Energy tissue welding encompasses laser and radio frequency energy tissue welding. While laser welding poses a risk of thermal damage, radio frequency welding offers significant advantages, including faster, seamless anastomosis with reduced complications. The support method for intestinal anastomosis is a novel concept, involving the addition of support materials to the original anastomosis. It can be divided into composite and simple support methods. The simple support method, as evidenced by the "degradable internal scaffold method for digestive tract anastomosis" developed by Cai et al. in China, has demonstrated promising results in animal experiments. In conclusion, selecting the appropriate intestinal anastomosis technique depends on clinical scenarios to optimize surgical outcomes and reduce complications. The diverse technological advancements reviewed here present valuable opportunities for enhancing the quality and safety of intestinal surgery.

Perioperative Precision Medicine
Perspective
Open Access
A new era of intelligent decision support in the perioperative period: Innovative applications of artificial intelligence, big data, and large language models
Di Wang
Di Wang
Department of Biomedical Sciences, Pusat Kanser Tun Abdullah Ahmad Badawi, Universiti Sains Malaysia, Bertam, Kepala Batas, 13200 Pulau Pinang, Malaysia.
,
Shafinah Ahmad Suhaimi
Shafinah Ahmad Suhaimi
shafinahas@usm.my
Department of Biomedical Sciences, Pusat Kanser Tun Abdullah Ahmad Badawi, Universiti Sains Malaysia, Bertam, Kepala Batas, 13200 Pulau Pinang, Malaysia.
2026 Mar;4(1):67-70
https://doi.org/10.61189/319254ilybgm
Article Preview PDF CITE

Wang D, Ahmad Suhaimi S. A new era of intelligent decision support in the perioperative period: Innovative applications of artificial intelligence, big data, and large language models. Perioper Precis Med. 2026 Mar; 4 (1): 67-70. doi: 10.61189/319254ilybgm

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Perioperative management is essential for ensuring surgical safety and improving patient outcomes. With increasing surgical complexity and patient heterogeneity, traditional experience-based decision-making is no longer sufficient to meet the demands of precision medicine. Recent advances in artificial intelligence (AI), big data analytics, and large language models (LLMs) provide new opportunities to transform perioperative clinical decision support. AI-driven models enable accurate risk stratification and prediction of perioperative complications, while big data technologies facilitate multimodal data integration, real-time monitoring, and personalized intervention strategies. Meanwhile, LLMs enhance clinical communication, support medical documentation, and assist knowledge-based clinical decision-making through advanced natural language processing capabilities. However, despite rapid technological development, a comprehensive framework integrating AI, big data, and LLMs for perioperative intelligent decision-making remains insufficiently explored. This article reviews emerging applications of AI in preoperative risk assessment, intelligent anesthesia management, and postoperative complication prediction, and summarizes the role of big data in integrated clinical platforms and personalized treatment strategies. It also highlights the potential of  LLMs in patient education, clinical decision support systems, and automated knowledge synthesis. Overall, integrating AI, big data, and LLMs may establish an interpretable closed-loop perioperative decision-support ecosystem that improves surgical safety, clinical efficiency, and personalized healthcare delivery.

Perioperative Precision Medicine
Review Article
Open Access
Emerging pharmacological strategies for neuropathic pain: Mechanism-based targeting and precision medicine
Rui Zhao
Rui Zhao
Zhaoruihl@163.com
Clinical College of Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China.
2026 Sep;4(3):313-341
https://doi.org/10.61189/986324cwpmgi
Article Preview PDF CITE
Zhao R. Emerging pharmacological strategies for neuropathic pain: Mechanism-based targeting and precision medicine. Perioper Precis Med. 2026 Sep; 4 (3): 313-341. doi: 10.61189/986324cwpmgi
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Neuropathic pain (NP) is a type of chronic pain syndrome due to structural or functional alterations in the somatosensory nervous system after injury, including long-lasting painful sensations and allodynia and hyperalgesia. Due to its intricate pathophysiology and significant interindividual variation in therapeutic response, the current pharmacological approaches are constrained by suboptimal efficacy and potential adverse effects. Recent evidence emphasizes maladaptive neuronal plasticity, neuroinflammatory and neurotransmitter system abnormalities as the main components mediating NP initiation and maintenance, with glial activation, ion channel dysfunction, and neuroimmune interactions being critical for central sensitization and pain maintenance. There have been advances in molecular understanding leading to new therapeutic targets with the emergence of inflammatory signalling pathways, ion channels, and neurotrophic factor-related networks. At the same time, emerging therapeutic strategies, including molecularly targeted agents, biologics, regenerative approaches and experimental nanodelivery platforms, are expanding precision approaches to NP. However, successful clinical translation remains challenging due to limitations in disease modelling, target specificity and patient heterogeneity. The merging of pharmacogenomics and multi-omics data is even unlocking further individualized analgesic strategies, which, alongside neuromodulation techniques and multidisciplinary care models, are promising new routes for long-term pain management. This Review outlines the major pathogenic mechanisms of NP, summarizes conventional and emerging pharmacological strategies, critically evaluates translational barriers that have limited clinical success, and discusses future directions for biomarker-guided personalized analgesic therapy.
Progress in Medical Devices
Research Article
Open Access
An influenza forecasting model based on RG-EEMD-TFT
Defu Lin
Defu Lin
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Zhaoxue Chen
Zhaoxue Chen
chenzhaoxue@163.com
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
2026 Sep;4(3):256-268
https://doi.org/10.61189/533372paermj
Article Preview PDF CITE
Lin DF, Chen ZX. An influenza forecasting model based on RG-EEMD-TFT. Prog Med Devices. 2026 Sep; 4 (3): 256-268. doi: 10.61189/533372paermj
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Objective: To improve the accuracy of influenza forecasting, this study proposes a Reconstruction Grouping–Ensemble Empirical Mode Decomposition–Temporal Fusion Transformer (RG-EEMD-TFT) model designed to address the nonlinear, non-stationary, and multi-scale characteristics of influenza surveillance time series, while addressing the limitations of conventional deep learning models in terms of feature redundancy and interpretability. Methods: Weekly influenza-like illness (ILI) data from Colorado, USA, were used in this study. Ensemble Empirical Mode Decomposition (EEMD) was first applied to decompose the original series into several intrinsic mode functions and a residual component. A reconstruction grouping (RG) strategy was then used to reorganize the decomposed signals into high-frequency, seasonal, and trend components, which were subsequently used as inputs to a Temporal Fusion Transformer (TFT). Hyperparameter optimization was performed using the Neural Network Intelligence (NNI) framework. Results: Models incorporating signal decomposition consistently outperformed their non-decomposed counterparts. The proposed RG-EEMD-TFT model outperformed all comparison models, achieving a mean absolute error (MAE) of 0.318, a mean absolute percentage error (MAPE) of 8.012%, and a root mean square error (RMSE) of 0.409. Conclusion: By integrating EEMD, reconstruction grouping, and TFT, the proposed RG-EEMD-TFT model effectively captures the multi-scale temporal characteristics of influenza activity and improves forecasting accuracy.
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