Siqi Wang*, Danhong Li*, Yina Zhang*, Yu Wang, Linrong Yuan, Miao Yu, Jianghui Li, Yimeng Wang, Ping Li
Faculty of Medical Instrumentation, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China.
*These authors are co-first authors.
Address correspondence to: Ping Li, Faculty of Medical Instrumentation, Shanghai University of Medicine and Health Sciences, 279 Zhouzhu Highway, Pudong New Area, Shanghai 201318, China. Tel: +86-13764055848. E-mail: lip@sumhs.edu.cn.
Declaration of ethics: The study was approved by the Ethics Review Committees of the Medical University of
Vienna and the University of Queensland.
Declaration of patient consent: The dataset underwent automated screening using neural networks, followed by
multiple manual reviews. All EXIF metadata were removed to eliminate any potentially identifiable information.
Therefore, the data are considered anonymized to the best of our knowledge.
DOI: https://doi.org/10.61189/446813bjkhvg
Received July 26, 2025; Accepted November 4, 2025; Published December 31, 2025
Highlights
● For the first time, the advantages of two deep learning architectures-SegNet and U-Net-were integrated by averaging their prediction outputs. This ensemble approach overcame the limitations of single models and substantially improved segmentation accuracy.
● The proposed Ensemble Model outperformed both SegNet and U-Net across all major evaluation metrics, including the Intersection over Union (IoU, 93.73%), Dice coefficient (84.85%), precision (93.93%), and loss (0.63), confirming the effectiveness of multi-method fusion.
● Considering the complex morphology and indistinct lesion boundaries characteristic of skin diseases, a standardized preprocessing and data augmentation pipeline was developed to enhance the model' s robustness in handling diverse lesion patterns.
Research Article |Published on: 31 December 2025
[Progress in Medical Devices] 2025; 3 (4): 223-233